Granulocyte-colony stimulating factor enhances the expression of transforming growth factor-beta mRNA in CD4-positive peripheral blood lymphocytes in the donors for allogeneic peripheral blood stem cell transplantation.

Autor: Hirayama Y; Fourth Department Internal Medicine, Sapporo Medical University, Sapporo, Japan. hira950712@aol.com, Sakamaki S, Matsunaga T, Kuroda H, Kusakabe T, Akiyama T, Kato J, Kogawa K, Koyama R, Nagai T, Ohta H, Niitsu Y
Jazyk: angličtina
Zdroj: American journal of hematology [Am J Hematol] 2002 Feb; Vol. 69 (2), pp. 138-40.
DOI: 10.1002/ajh.10027
Abstrakt: The degree of acute graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (allo-PBSCT) has been observed to be, unexpectedly, of an equal level to that after bone marrow transplantation. To explain this phenomenon, we hypothesized that granulocyte-colony stimulating factor (G-CSF) administration may induce transforming growth factor (TGF)-beta producing T cells in the donors. Five donors received 10 microg/kg G-CSF subcutaneously for 4 days. The TGFbeta mRNA expression in CD4(+) cells as measured by real time reverse transcription-polymerase chain reaction increased after G-CSF administration. This elevation is considered to be one additive mechanism of repression of acute GVHD after allo-PBSCT.
(Copyright 2002 Wiley-Liss, Inc.)
Databáze: MEDLINE
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