| Autor: |
Robles MS; Department of Immunology and Oncology, Centro Nacional de Biotecnología, Universidad Autónoma de Madrid, Madrid Campus de Cantoblanco, Madrid, Spain. msrobles@cnb.uam.es, Leonardo E, Criado LM, Izquierdo M, Martínez-A C |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2002 Feb 15; Vol. 168 (4), pp. 1770-9. |
| DOI: |
10.4049/jimmunol.168.4.1770 |
| Abstrakt: |
The inhibitors of apoptosis proteins (IAPs) constitute a family of endogenous inhibitors that control apoptosis in the cell by inhibiting caspase processing and activity. IAPs are also implicated in cell division, cell cycle regulation, and cancer. To address the role of IAPs in thymus development and homeostasis, we generated transgenic mice expressing IAP generated from the baculovirus Orgyia pseudotsugata nuclear polyhedrosis virus (OpIAP). Developing thymocytes expressing OpIAP show increased nuclear levels of NF-kappaB and reduced cytoplasmic levels of its inhibitor, IkappaBalpha. In mature thymocytes, OpIAP induces optimal activation and proliferation after TCR triggering in the absence of a costimulatory signal. OpIAP expression in immature thymocytes blocks TCR-induced apoptosis. Taken together, our data illustrate the pleiotropism of OpIAP in vivo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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