| Autor: |
Fahy J; Division de Chimie Médicinale V, Centre de Recherche Pierre Fabre, 81106 Castres, France. jacques.fahy@pierre-fabre.com, Thillaye du Boullay V, Bigg DC |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Feb 11; Vol. 12 (3), pp. 505-7. |
| DOI: |
10.1016/s0960-894x(01)00784-3 |
| Abstrakt: |
Vinblastine and vinorelbine analogues have been synthesised by reacting new versatile electrophilic vindoline derivatives with various 3-substituted indoles. The resulting compounds have been evaluated for their antimitotic properties, but exhibited less potent activities in comparison with the standard binary Vinca alkaloids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect