| Autor: |
Steele JC; Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3DS, UK., Veitch NC, Kite GC, Simmonds MS, Warhurst DC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2002 Jan; Vol. 65 (1), pp. 85-8. |
| DOI: |
10.1021/np0101705 |
| Abstrakt: |
The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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