A new triterpene saponin from Pittosporum viridiflorum from the Madagascar rainforest.
Grant Information: | U01 TW/CA 00313 United States TW FIC NIH HHS |
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Substance Nomenclature: | 0 (Antineoplastic Agents, Phytogenic) 0 (Saponins) 0 (Triterpenes) 0 (pittoviridoside) 6SMK8R7TGJ (Oleanolic Acid) |
Entry Date(s): | Date Created: 20020126 Date Completed: 20020326 Latest Revision: 20190906 |
Update Code: | 20221213 |
DOI: | 10.1021/np010327t |
PMID: | 11809069 |
Autor: | Seo Y; Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA., Berger JM, Hoch J, Neddermann KM, Bursuker I, Mamber SW, Kingston DG |
Jazyk: | angličtina |
Zdroj: | Journal of natural products [J Nat Prod] 2002 Jan; Vol. 65 (1), pp. 65-8. |
DOI: | 10.1021/np010327t |
Abstrakt: | A novel triterpenoid saponin, pittoviridoside (1), which possesses an unusual 2,3,4-trisubstituted glycosidic linkage, has been isolated from Pittosporum viridiflorum using the engineered yeast strains 1138, 1140, 1353, and Sc-7 for bioactivity-guided fractionation. The structure of this compound was determined to be 3-O-[beta-D-glucopyranosyl(1-->2)]-[alpha-D-arabinopyranosyl(1-->3)],[alpha-l-arabinofuranosyl(1-->4)-beta-D-glucuronopyranosyl-21-angeloyl-22-senecioylolean-12-en-3beta,15alpha,16alpha,21beta,22alpha,28-hexol by spectral, chemical, and GC analyses. This compound showed weak cytotoxicity against the A2780 human ovarian cancer cell line. |
Databáze: | MEDLINE |
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