A new triterpene saponin from Pittosporum viridiflorum from the Madagascar rainforest.

2)]-[alpha-D-arabinopyranosyl(1-->3)],[alpha-l-arabinofuranosyl(1-->4)-beta-D-glucuronopyranosyl-21-angeloyl-22-senecioylolean-12-en-3beta,15alpha,16alpha,21beta,22alpha,28-hexol by spectral, chemical, and GC analyses. This compound showed weak cytotoxicity against the A2780 human ovarian cancer cell line. -->
Grant Information: U01 TW/CA 00313 United States TW FIC NIH HHS
Substance Nomenclature: 0 (Antineoplastic Agents, Phytogenic)
0 (Saponins)
0 (Triterpenes)
0 (pittoviridoside)
6SMK8R7TGJ (Oleanolic Acid)
Entry Date(s): Date Created: 20020126 Date Completed: 20020326 Latest Revision: 20190906
Update Code: 20221213
DOI: 10.1021/np010327t
PMID: 11809069
Autor: Seo Y; Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA., Berger JM, Hoch J, Neddermann KM, Bursuker I, Mamber SW, Kingston DG
Jazyk: angličtina
Zdroj: Journal of natural products [J Nat Prod] 2002 Jan; Vol. 65 (1), pp. 65-8.
DOI: 10.1021/np010327t
Abstrakt: A novel triterpenoid saponin, pittoviridoside (1), which possesses an unusual 2,3,4-trisubstituted glycosidic linkage, has been isolated from Pittosporum viridiflorum using the engineered yeast strains 1138, 1140, 1353, and Sc-7 for bioactivity-guided fractionation. The structure of this compound was determined to be 3-O-[beta-D-glucopyranosyl(1-->2)]-[alpha-D-arabinopyranosyl(1-->3)],[alpha-l-arabinofuranosyl(1-->4)-beta-D-glucuronopyranosyl-21-angeloyl-22-senecioylolean-12-en-3beta,15alpha,16alpha,21beta,22alpha,28-hexol by spectral, chemical, and GC analyses. This compound showed weak cytotoxicity against the A2780 human ovarian cancer cell line.
Databáze: MEDLINE
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