| Autor: |
Shoemaker MO; Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889, USA. shoemaker@mx.afrri.usuhs.mil, Tammariello R, Crise B, Bouhaouala SS, Knudson GB, Jackson WE 3rd, Ludwig GV, Smith JF |
| Jazyk: |
angličtina |
| Zdroj: |
Military medicine [Mil Med] 2001 Dec; Vol. 166 (12 Suppl), pp. 88-9. |
| Abstrakt: |
The combined effects of injury from exposure to ionizing radiation and the potential biological warfare agent Venezuelan equine encephalitis (VEE) virus remain largely unknown. To study these effects, 4- to 5-week-old B6D2F1/J female mice were given a sublethal whole-body 7 Gy dose of 60Co gamma-photon radiation followed 48 hours later by aerosol or intraperitoneal challenge with enzootic VEE IIIA virus. Survival was observed for 30 days. A single sublethal 7 Gy dose of gamma radiation reduced the LD50/30 of VEE IIIA virus, in intraperitoneal challenged mice by a factor of 10(4) from 1.1 x 10(6) plaque-forming units (pfu) to 1 x 10(2) pfu, and in aerosol challenged mice, by a factor of 5 from 70 pfu to 14 pfu. These findings further confirm there is a combined effect of exposure to ionizing radiation and biological warfare agents, which could be devastating to unprotected populations and thus should be investigated further. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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