| Autor: |
Westin Kwon K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA., Lendvai N, Morrison S, Trinh KR, Casadevall A |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and diagnostic laboratory immunology [Clin Diagn Lab Immunol] 2002 Jan; Vol. 9 (1), pp. 201-4. |
| DOI: |
10.1128/cdli.9.1.201-204.2002 |
| Abstrakt: |
The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the parent MAb, exhibits biological activity, and lacks the toxicity of the parent murine IgG1 in chronically infected mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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