| Autor: |
Chung I; The Center for Neurovirology and Neurodegenerative Disorders, Departments of Pathology and Microbiology, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198-5215, USA., Zelivyanskaya M, Gendelman HE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroimmunology [J Neuroimmunol] 2002 Jan; Vol. 122 (1-2), pp. 40-54. |
| DOI: |
10.1016/s0165-5728(01)00462-3 |
| Abstrakt: |
Mononuclear phagocyte (MP) brain migration influence neuronal damage during HIV-1-associated dementia (HAD). We demonstrate that potassium channels, expressed in human monocyte-derived macrophages (MDM), are vital for MP movement through Boyden chemotactic chambers, an artificial blood-brain barrier and organotypic hippocampal brain slices. MDM migration is inhibited by voltage-and calcium-activated potassium channel blockers that include charybodotoxin, margatoxin, agatoxin and apamin. This is observed both in uninfected and HIV-1-infected MP. The results suggest that potassium channels affect MDM brain migration through altering cell volume and shape. Such mechanisms likely affect MP-induced neuronal destruction during HAD. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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