[Characteristics of the rat behavior following single and multiple exposures of the hypoglycemic insulin doses].

Autor: Shestakova SA; St. Petersburg I. P. Pavlov State Medical University, St. Petersburg, 197022, Leo Tolstoy St., 6/8, Russia., Eliseeva AP, Lebedev AA, Shabaev VV, Makarova TM, Klimenko VM
Jazyk: ruština
Zdroj: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2001 Oct; Vol. 87 (10), pp. 1341-50.
Abstrakt: Rats behaviour in the "open field" changed in 2 hrs after a single episode of hypoglycaemia was abolished with glucose whereas no changes occurred in their stereotyped behaviour and intraspecies interaction. In 24 hrs quantitative parameters of the "open field" behaviour normalised although the behaviour still had an altered structure. At the same time, amphetamine-induced stereotyped behaviour's indices became reduced. These and other findings suggest some deeper behavioural changes in rats during their recovery from repeated hypoglycaemic episodes and absence of synchronisation of the insulin effects.
Databáze: MEDLINE