| Autor: |
Myung PS; Graduate Program in Immunology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA., Derimanov GS, Jordan MS, Punt JA, Liu QH, Judd BA, Meyers EE, Sigmund CD, Freedman BD, Koretzky GA |
| Jazyk: |
angličtina |
| Zdroj: |
Immunity [Immunity] 2001 Dec; Vol. 15 (6), pp. 1011-26. |
| DOI: |
10.1016/s1074-7613(01)00253-9 |
| Abstrakt: |
The hematopoietic cell-specific adaptor protein, SLP-76, is critical for T cell development and mature T cell receptor (TCR) signaling; however, the structural requirements of SLP-76 for mediating thymopoiesis and mature T cell function remain largely unknown. In this study, transgenic mice were generated to examine the requirements for specific domains of SLP-76 in thymocytes and peripheral T cells in vivo. Examination of mice expressing various mutants of SLP-76 on the null background demonstrates a differential requirement for specific domains of SLP-76 in thymocytes and T cells and provides new insight into the molecular mechanisms underlying SLP-76 function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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