Lecithin: cholesterol acyltransferase is insufficient to prevent oxidative modification of low-density lipoprotein.

Autor: Murakami Y; Laboratory of Nutrition, Graduate School of Agricultural Science, and Gene Research Center, Tohoku University, Tsutsumidori, Amamiya-machi, Aoba-ku, Sendai 981-8555, Japan., Kamiyama S, Howlader ZH, Yamato T, Komai M, Furukawa Y
Jazyk: angličtina
Zdroj: Journal of biochemistry [J Biochem] 2002 Jan; Vol. 131 (1), pp. 17-9.
DOI: 10.1093/oxfordjournals.jbchem.a003072
Abstrakt: We tried to confirm the antioxidative capability of lecithin:cholesterol acyltransferase (LCAT) reported by Vohl et al. [Biochemistry (1999) 38, 5976-5981]. The enzyme solution protected LDL against oxidation. However, this protection was not due to LCAT enzyme, but to some unknown low-molecular-weight substance(s) in the solution; LCAT itself exerted little protective effect against LDL oxidation.
Databáze: MEDLINE