Isolated mental developmental delay in very low birth weight infants: association with prolonged doxapram therapy for apnea.

Autor: Sreenan C; Neonatal Intensive Care Unit and Department of Perinatology, Royal Alexandra Hospital, Edmonton, Alberta, Canada., Etches PC, Demianczuk N, Robertson CM
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2001 Dec; Vol. 139 (6), pp. 832-7.
DOI: 10.1067/mpd.2001.119592
Abstrakt: Objective: We investigated factors associated with isolated mental delay in infants weighing < 1250 g at birth.
Study Design: With a case-control design, matching variables for 40 cases included gestation, birth weight, sex, grade of intraventricular hemorrhage, and socioeconomic status. Case subjects had a mental developmental index < 70, and controls had a mental developmental index > or = 85, according to the Bayley Scales of Infant Development II at 18 months' corrected age.
Results: There were no differences between the case and control subjects for neonatal complications and antenatal or postnatal steroid use. There was a marked difference in the cumulative dosage and duration of doxapram therapy used for apnea of prematurity (total dose 2233 +/- 1927 mg vs 615 +/- 767 mg, P < .001; duration 45.2 +/- 32.5 days vs 19.4 +/- 23.4 days, P < .001 for case subjects and control subjects, respectively). Multivariate analysis did not identify additive predictive variables.
Conclusion: Isolated mental delay in infants weighing < 1250 g at birth was associated with the total dosage and duration of doxapram therapy for severe apnea. Although this may be a marker for cerebral dysfunction manifesting as apnea of prematurity, possible adverse effects of doxapram or its preservative, benzyl alcohol, on the developing brain deserve further study.
Databáze: MEDLINE
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