Vulvar melanoma: a retrospective analysis and literature review.

Autor: Irvin WP Jr; Division of Gynecologic Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA. wpi9d@hscmail.mcc.virginia.edu, Legallo RL, Stoler MH, Rice LW, Taylor PT Jr, Andersen WA
Jazyk: angličtina
Zdroj: Gynecologic oncology [Gynecol Oncol] 2001 Dec; Vol. 83 (3), pp. 457-65.
DOI: 10.1006/gyno.2001.6337
Abstrakt: Objective: This review focuses on current directions in the staging and treatment of melanoma of the vulva.
Methods: All women treated for invasive melanoma of the vulva at the University of Virginia Health Sciences Center from 1980 through 2000 were identified through a retrospective review of the records of the Division of Gynecologic Oncology. Their treatments and outcomes were then analyzed and presented.
Results: Over the 20-year study period, 14 cases of melanoma of the vulva were identified. Of the 14 patients treated with curative intent, 6 developed recurrences following the completion of primary therapy, and all are dead from their disease. The mean duration from completion of therapy to recurrence was 7.5 months; the mean survival following recurrence was 17 months.
Conclusion: One-centimeter skin margins appear adequate for vulvar melanomas <1 mm thick, and 2-cm margins appear adequate for intermediate-thickness melanomas (1-4 mm). In all cases it is necessary to include at least a 1-cm-deep margin extending through the subcutaneous fat to the muscular fascia below. Elective node dissection seems to offer no additional advantage in superficial lesions <0.76 mm thick, and its role in deeper lesions is still uncertain.
((c)2001 Elsevier Science.)
Databáze: MEDLINE
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