New glimpses of an old machine.

Autor: Paull TT; Department of Molecular Genetics and Microbiology and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. tpaull@icmb.utexas.edu
Jazyk: angličtina
Zdroj: Cell [Cell] 2001 Nov 30; Vol. 107 (5), pp. 563-5.
DOI: 10.1016/s0092-8674(01)00591-8
Abstrakt: Two recent studies illustrate the ability of the Mre11/Rad50 DNA repair complex to bind and connect DNA ends. Specific stimulation of DNA ligase IV-mediated end-joining by Mre11 complexes from S. cerevisiae suggests the possibility of a direct role in nonhomologous end-joining in eukaryotic cells.
Databáze: MEDLINE