| Autor: |
Gudmundsson KS; Division of Chemistry, Glaxo Wellcome Inc, Research Triangle Park, NC 27709, USA., Wang Z, Daluge SM, Feldman PL |
| Jazyk: |
angličtina |
| Zdroj: |
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2001 Oct-Nov; Vol. 20 (10-11), pp. 1823-30. |
| DOI: |
10.1081/NCN-100107193 |
| Abstrakt: |
Syntheses and antiviral activity of new carbocyclic analogs of 2', 3'-dideoxysangivamycin, 2',3'-dideoxytoyocamycin and 2',3'-dideoxytriciribine is described. The key intermediate, carbocyclic 4-chloro-5-iodopyrrolopyrimidine. was synthesized in good yield via a novel iodination method using I2 and CF3COOAg. This carbocyclic 4-chloro-5-iodopyrrolopyrimidine then allowed for a concise synthesis of the desired 4,5-disubstituted carbocyclic nucleosides. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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