| Autor: |
Rodriguez ME; Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands. mer@quimica.unlp.edu.ar, Hellwig SM, Hozbor DF, Leusen J, van der Pol WL, van de Winkel JG |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2001 Dec 01; Vol. 167 (11), pp. 6545-51. |
| DOI: |
10.4049/jimmunol.167.11.6545 |
| Abstrakt: |
The relevance of specific Abs for the induction of cellular effector functions against Bordetella pertussis was studied. IgG-opsonized B. pertussis was efficiently phagocytosed by human polymorphonuclear leukocytes (PMN). This process was mediated by the PMN IgG receptors, FcgammaRIIa (CD32) and FcgammaRIIIb (CD16), working synergistically. Furthermore, these FcgammaR triggered efficient PMN respiratory burst activity and mediated transfer of B. pertussis to lysosomal compartments, ultimately resulting in reduced bacterial viability. Bacteria opsonized with IgA triggered similar PMN activation via FcalphaR (CD89). Simultaneous engagement of FcalphaRI and FcgammaR by B. pertussis resulted in increased phagocytosis rates, compared with responses induced by either isotype alone. These data provide new insights into host immune mechanisms against B. pertussis and document a crucial role for Ig-FcR interactions in immunity to this human pathogen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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