| Autor: |
Urban JF Jr; U.S. Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Immunology and Disease Resistance Laboratory, Beltsville, MD 20705, USA., Noben-Trauth N, Schopf L, Madden KB, Finkelman FD |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2001 Dec 01; Vol. 167 (11), pp. 6078-81. |
| DOI: |
10.4049/jimmunol.167.11.6078 |
| Abstrakt: |
Expulsion of two gastrointestinal nematode parasites, Nippostrongylus brasiliensis and Trichinella spiralis, is similar in that both require IL-4Ralpha expression, but different in that T cells and mast cells are required for IL-4-induced expulsion of T. spiralis but not N. brasiliensis. To examine the role of IL-4Ralpha signaling in immunity to these parasites, we studied worm expulsion in chimeric mice that selectively expressed IL-4Ralpha on bone marrow-derived or non-bone marrow-derived cells. N. brasiliensis was expelled by mice that expressed IL-4Ralpha only on non-bone marrow-derived cells, but not by mice that expressed IL-4Ralpha only on bone marrow-derived cells. Although T. spiralis expulsion required IL-4Ralpha expression by both bone marrow- and non-bone marrow-derived cells, IL-4 stimulation eliminated the requirement for IL-4Ralpha expression by bone marrow-derived cells. Thus, direct IL-4Ralpha signaling of nonimmune gastrointestinal cells may be generally required to induce worm expulsion, even when mast cell and T cell responses are also required. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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