Comparative analysis of age-related changes in activities of monoamine oxidase-B and antioxidant defense enzymes in various structures of human brain.

Autor: Volchegorskii IA; Department of General and Bioorganic Chemistry, Chelyabinsk State Medical Academy., Shemyakov SE, Turygin VV, Malinovskaya NV
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2001 Aug; Vol. 132 (2), pp. 760-2.
DOI: 10.1023/a:1013081912452
Abstrakt: Activities of monoamine oxidase B, Cu-Zn-dependent superoxide dismutase (SOD), and catalase, and concentration of enzyme-active ceruloplasmin were measured in brain preparations from 43 humans died at the age of 21-92 years. Activity of monoamine oxidase B in the neocortex, cerebellum, basal ganglia, and stem structures increased with age, while SOD activity decreased and catalase and ceruloplasmin concentrations slightly increased. A contribution of age-related increase of cerebral monoamine oxidase activity into ontogenetic impairment of the antioxidant defense in human brain is discussed.
Databáze: MEDLINE
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