| Autor: |
Yan L; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Stanley SL Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 2001 Dec; Vol. 69 (12), pp. 7911-4. |
| DOI: |
10.1128/IAI.69.12.7911-7914.2001 |
| Abstrakt: |
We looked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection. A dose of the pan-caspase inhibitor benzyloxycarbonyl-V-A-D-O-methyl fluoromethyl ketone (Z-VAD-FMK; R & D Systems) given to SCID mice 2 h prior to direct hepatic inoculation with Entamoeba histolytica trophozoites, and 12 h after amebic inoculation, reduced the mean liver abscess size by 70% at 24 h compared to a control group. These data indicate that apoptosis plays a significant but not an exclusive role in amebic liver abscess formation in the mouse model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
