Therapeutic immune reconstitution in HIV-1-infected children is independent of their age and pretreatment immune status.
| Autor: | van Rossum AM; Department of Paediatrics, Sophia Children's Hospital/Erasmus University Medical Centre, 3000 LL Rotterdam, the Netherlands., Scherpbier HJ, van Lochem EG, Pakker NG, Slieker WA, Wolthers KC, Roos MT, Kuijpers JH, Hooijkaas H, Hartwig NG, Geelen SP, Wolfs TF, Lange JM, Miedema F, de Groot R |
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| Jazyk: | angličtina |
| Zdroj: | AIDS (London, England) [AIDS] 2001 Nov 23; Vol. 15 (17), pp. 2267-75. |
| DOI: | 10.1097/00002030-200111230-00008 |
| Abstrakt: | Objective: To evaluate long-term immune reconstitution of children treated with highly active antiretroviral therapy (HAART). Methods: The long-term immunological response to HAART was studied in 71 HIV-1-infected children (aged 1 month to 18 years) in two prospective, open, uncontrolled national multicentre studies. Blood samples were taken before and after HAART was initiated, with a follow-up of 96 weeks, and peripheral CD4 and CD8 T cells plus naive and memory subsets were identified in whole blood samples. Relative cell counts were calculated in relation to the median of the age-specific reference. Results: The absolute CD4 cell count and percentage and the CD4 cell count as a percentage of normal increased significantly (P < 0.001) to medians of 939 x 106 cells/l (range, 10-3520), 32% (range, 1-50) and 84% (range, 1-161), respectively, after 48 weeks. This increase was predominantly owing to naive CD4 T cells. There was a correlation between the increase of absolute naive CD4 T cell counts and age. However, when CD4 T cell restoration was studied as percentage of normal values, the inverse correlation between the increase of naive CD4 T cell count and age was not observed. In addition, no difference in immunological reconstitution was observed at any time point between virological responders and non-responders. Conclusions: Normalization of the CD4 cell counts in children treated with HAART is independent of age, indicating that children of all age groups can meet their CD4 T cell production demands. In general, it appears that children restore their CD4 T cell counts better and more rapidly than adults, even in a late stage of HIV-1 infection. |
| Databáze: | MEDLINE |
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