| Autor: |
Craver RD; Department of Pathology, Louisiana State University Medical Center, New Orleans, LA, USA. rcrave@lsuhsc.edu, Scheer WD, Correa H, Vehaskari VM, Yu LC |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2001 Nov; Vol. 125 (11), pp. 1480-2. |
| DOI: |
10.5858/2001-125-1480-HLIART |
| Abstrakt: |
Posttransplant lymphoproliferative disorders are often accompanied by >500 Epstein-Barr virus (EBV) genome copies/10(5) lymphocytes, and they occur shortly after transplantation. Hodgkin lymphoma occurs rarely after transplantation, appearing a mean of 4.2 years posttransplant, and although Hodgkin lymphoma has strong associations with EBV, no quantitative analysis of peripheral blood EBV genome copies has been reported. A mixed cellularity Hodgkin lymphoma developed in a 17-year-old boy 4 years after a renal transplant. Serial EBV genome copy numbers from blood by competitive polymerase chain reaction had been obtained to assess for lymphoproliferative disease. Epstein-Barr virus genome copy numbers peaked at 500 copies/10(5) lymphocytes 8 months prior to Hodgkin lymphoma diagnosis but fell to 8 copies/10(5) lymphocytes at diagnosis. Reliance on EBV levels greater than 500 copies may result in delay of biopsy and diagnosis of Hodgkin disease in the posttransplant setting. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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