| Autor: |
Tesseromatis C; Department of Pharmacology, Medical School, University of Athens, Greece., Trichilis A, Tsivos E, Messari J, Triantaphyllidis H, Varonos DD |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2001 Jul-Sep; Vol. 26 (3), pp. 167-71. |
| DOI: |
10.1007/BF03190392 |
| Abstrakt: |
Exercise produces changes of drug levels in plasma and increases the concentration of free fatty acids (FFAs), which may interfere with drug-protein binding. FFAs seem to play an antagonistic role to drugs since they have a strong binding capacity to serum albumin. The aim of this study was to evaluate the influence of the consecutive exercise-induced stress in ampicillin levels. Two groups of Wistar rats were used. Group A consisted of six subgroups that were subjected to cold swimming (4 degrees C) for 5, 10, 15, 20,25, 30 days respectively. Group B was the control group. The animals were injected im. with ampicillin (1 g/Kg/8h in 5 doses). Results showed that exercise enhanced stress parameters (FFAs, adrenal weight, Ht%) and led to an ampicillin increase in all experimental groups comparatively to controls. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink