[ACE-dependent and sympathetic components of blood pressure regulation in patients with essential hypertension].

Autor:	Aparina TV; National Research Centre for Preventive Medicine, Pogodinskaja St., 10, Moscow, Russia, 119992 Moscow., Gomazkov OA, Dilakian EA, Britov AN
Jazyk:	ruština
Zdroj:	Voprosy meditsinskoi khimii [Vopr Med Khim] 2001 Jul-Aug; Vol. 47 (4), pp. 411-8.
Abstrakt:	Unlabelled: The development of arterial hypertension is accompanied by impairment of the normal ratio of the "ACE-depending" and of the sympathetic nervous system, correlates with the action on the main pharmacological "targets": I-I-imidazoline receptors (moxonidine) or the ACE activity (enalapril). The aim of the present investigation was to determine the hypotensive and metabolic effects of moxonidine and enalapril depending on the basal ACE activity in patients with arterial hypertension, complicated with the metabolic syndrome. Effectiveness of moxonidine and enalapril administration (during 24 weeks) depended on the basal ACE activity in the hypertensive patients: (a) in the group of patients with low basal ACE activity moxonidine very effectively decreased systolic and diastolic blood pressure, compared with the group of patients with high basal ACE activity; (b) influence of enalapril on the level of arterial blood pressure was more pronounced with high basal ACE activity. In Conclusion: choosing a hypotensive treatment for patients with the metabolic syndrome, it is advisable to take into account the basal ACE activity levels.
Databáze:	MEDLINE
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