Experimental gonococcal urethritis and reinfection with homologous gonococci in male volunteers.

Autor:	Schmidt KA; Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC, USA. katherine.a.schmidt@dartmouth.edu, Schneider H, Lindstrom JA, Boslego JW, Warren RA, Van de Verg L, Deal CD, McClain JB, Griffiss JM
Jazyk:	angličtina
Zdroj:	Sexually transmitted diseases [Sex Transm Dis] 2001 Oct; Vol. 28 (10), pp. 555-64.
DOI:	10.1097/00007435-200110000-00001
Abstrakt:	Background: Reinfection, a common occurrence with gonorrhea, may result from a lack of protective immune response, or from the tremendous gonococcal strain variation. Goal: A two-phase study in human volunteers tested whether experimental infection with Neisseria gonorrhoeae MS11mkC would protect against reinfection with the same organisms. Study Design: In phase 1, an intraurethral inoculum of 57,000 piliated, transparent (opacity protein-negative [Opa-]) MS11mkC N gonorrhoeae infected 14 of 15 (93%) volunteers. The volunteers were encouraged to delay treatment for at least 5 days. In phase 2, which began 2 weeks after treatment for the initial infection, volunteers were inoculated with 7,100 piliated, Opa- MS11mkC. Results: The phase 2 challenge infected 6 of 14 (43%) previously infected volunteers and 5 of 10 (50%) naïve control subjects. Phase 1 volunteers who resisted reinfection were significantly more likely to have had a fourfold or greater increase in lipooligosaccharide immunoglobulin G during phase 1 than those who did not resist reinfection (P = 0.026). Conclusions: Although infection did not provide protection from reinfection under the conditions used, the results suggest that immunity to reinfection is more complex than anticipated by the experimental design.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu