Biocompatibility of Trillium Biopassive Surface-coated oxygenator versus uncoated oxygenator during cardiopulmonary bypass.

Autor: Ereth MH; Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA., Nuttall GA, Clarke SH, Dearani JA, Fiechtner BK, Rishavy CR, Buda DA, Shaw TA, Orszulak TA, Oliver WC Jr
Jazyk: angličtina
Zdroj: Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2001 Oct; Vol. 15 (5), pp. 545-50; discussion 539-41.
DOI: 10.1053/jcan.2001.26525
Abstrakt: Objective: To determine if the Trillium Biopassive Surface (Medtronic Cardiopulmonary, Minneapolis, MN) coating added to the cardiopulmonary bypass oxygenator reduces inflammatory mediators, blood loss, and transfusion requirements.
Design: Prospective, randomized, and blinded human trial.
Setting: Tertiary care academic medical center.
Participants: Thirty adult patients undergoing elective coronary artery bypass graft surgery.
Interventions: Patients received visually identical coated or uncoated oxygenators.
Measurements and Main Results: Hemoglobin, hematocrit, leukocyte count, platelet count, terminal complement complex, complement activation, myeloperoxidase, beta-thromboglobulin, prothrombin fragment 1.2, plasmin-antiplasmin, heparin concentration, activated coagulation time, and fibrinogen concentration were measured. Blood loss and blood product usage were recorded. In both groups, there were significant inflammatory alterations with the initiation of cardiopulmonary bypass. In the postprotamine samples, the coated oxygenator group had small but significant increases in hemoglobin, hematocrit, and leukocyte count. There were no differences in inflammatory mediators, blood loss, or transfusion requirements between the coated and uncoated groups.
Conclusion: This human trial of Trillium Biopassive Surface-coated oxygenators did not show clinical benefits or clinically important biochemical results.
(Copyright 2001 by W.B. Saunders Company)
Databáze: MEDLINE
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