| Autor: |
Betancur-Galvis L; Grupo Inmunovirología-Biogénesis, Universidad de Antioquia, A.A1226, Medellín-Colombia, Spain. labeta@catios.udea.edu.co, Zuluaga C, Arnó M, González MA, Zaragozá RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2001 Oct; Vol. 64 (10), pp. 1318-21. |
| DOI: |
10.1021/np010207l |
| Abstrakt: |
Fourteen semisynthetic compounds derived from the natural scopadulane-type diterpenes thyrsiflorin A (4), B (5), and C (6), including several precursors, have been examined in vitro for their antiherpetic activity against Herpes simplex virus type II (HSV-2) and cytotoxicity against two human tumor cell lines. Four of these compounds showed moderate antiherpetic activity, but none of them exhibited a significant cytotoxicity against the cell lines used. Some structure-activity relationships have been identified for the antiviral activity in these scopadulane derivatives as well as important structural features for the cytotoxic activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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