[Production of recombinant endostatin in milk from transgenic mice].

Autor: Zavadskaia ES; Institute of Gene Biology, Russian Academy of Sciences, Moscow, 117334 Russia., Zakharova ES, Kadulin SG, Kibardin AV, Kiselev SL, Gnuchev NV
Jazyk: ruština
Zdroj: Genetika [Genetika] 2001 Sep; Vol. 37 (9), pp. 1207-12.
Abstrakt: Using the bovine alpha S1-casein gene, a genetic construct with an endostatin-coding fragment of the mouse collagen XVIII cDNA was designed to express endostatin in milk of transgenic animals. Several transgenic mice were obtained. The mice secreted endostatin in milk at 70-300 ng/microliter and transmitted this character to their progeny.
Databáze: MEDLINE