| Autor: |
Langlois N; Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France. nicole.langlois@icsn.cnrs-gif.fr, Rojas-Rousseau A, Gaspard C, Werner GH, Darro F, Kiss R |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 2001 Oct 25; Vol. 44 (22), pp. 3754-7. |
| DOI: |
10.1021/jm010937q |
| Abstrakt: |
A new 7,8-methylenedioxy analogue (4) of (+)-porothramycin B (2) and its water-soluble sodium bisulfite derivative (15) have been synthesized in high yields and have been shown to exhibit high cytotoxic activities against several tumor cell lines. The new pyrrolo[2,1-c][1,4]benzodiazepine 4 was as effective against the resistant cell lines as against the doxorubicin-sensitive cell lines tested. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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