| Autor: |
Kazimirchuk EV, Egorov EE, Karachentsev DN, Zelenin AV |
| Jazyk: |
ruština |
| Zdroj: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2001 Sep-Oct; Vol. 35 (5), pp. 908-11. |
| Abstrakt: |
EIn heterokaryons, DNA synthesis is reactivated in macrophage nuclei only in the case of fusion with immortal cells. Assuming that telomerase is responsible for reactivation, the effect of its inhibitor azidothymidine (AZT) was studied in heterokaryons of mouse resident peritoneal macrophages and immortal 3T3 Swiss cells. AZT suppressed reactivation of DNA synthesis in macrophage nuclei and had no effect on DNA synthesis in 3T3 Swiss cell nuclei, suggesting an altered telomere structure in normal mouse macrophages. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
