| Autor: |
Malygina NA; derjagin@ium.ips.ras.ru, Melent'ev AS, Kostomarova IV, Melent'ev IA, Saégitov RT, Smirnova IuB, Serova LD |
| Jazyk: |
ruština |
| Zdroj: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 2001 Sep-Oct; Vol. 35 (5), pp. 787-91. |
| Abstrakt: |
Allele and genotype frequencies of the HindIII polymorphism of the lipoprotein lipase (LPL) gene were studied in patients with myocardial infarction (MI) and stable angina of effort (SAE), including long-lived people (over 90). The polymorphism proved to be associated with MI and with the life span, genotype H+/H+ being predisposing to MI and allele H- being protective. The allele and genotype frequencies of long-lived people differed significantly from the Hardy-Weinberg proportions and from those of SAE patients aged up to 90. An excess of heterozygotes in this group suggests a selective pressure which eliminates homozygotes. Possibly, heterozygotes H+/H- have an adaptive advantage, which provides for their longevity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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