| Autor: |
Gorid'ko TM; Palladin Institute of Biochemistry, NAS of Ukraine., Hula NM, Marhitych VM, Hovseieva NM, Klimashevs'kyĭ VM, Shahidulin MIu |
| Jazyk: |
ukrajinština |
| Zdroj: |
Ukrains'kyi biokhimichnyi zhurnal (1999 ) [Ukr Biokhim Zh (1999)] 2001 Jan-Feb; Vol. 73 (1), pp. 82-7. |
| Abstrakt: |
The effect of N-palmitoylethanolamine (NPE, 10(-5) M) on the lipid peroxidation (LPO) processes, phospholipid and fatty acid content in the rat liver at perfusion and ischemia during the liver preservation was estimated. As early as at the 5th min of perfusion by cooled conserving solution "Eurocollins", LPO activation was determined. Simultaneously the content of lysophosphatidylcholine (LPC) and phosphatidylserine increased, the total cholesterol level decreased. The redistribution of saturated and unsaturated fatty acids quantity was detected. The addition of NPE into "Eurocollins" solution reduced the accumulation of malonedialdehyde and LPC, modified the fatty acids content. These effects, evidently, formed the basis of the protective action of NPE on the hepatic tissues under anoxia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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