| Autor: |
Baker DC, Haskell TH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1975 Oct; Vol. 18 (10), pp. 1041-4. |
| DOI: |
10.1021/jm00244a022 |
| Abstrakt: |
Preparation of both a 5'-deuterium and a 5'-tritium-labeled 9-beta-D-arabinofuranosyladenine (6a and 6b) by reduction of the protected 5'-aldehyde 4 is described. Conversion of 6b to the 5'-tritium-labeled 5'-monophosphate 7b was effected directly with a phosphoryl chloride-formic acid reagent. The product 7b exhibited consistently higher blood levels of nonvolatile tritium than the 2-labeled compound when tested in dogs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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