[Thrombogenic and endothelial damage markers in patients with ischemic systolic impairment].
| Autor: | Roldán Schilling V; Servicio de Cardiología. Hospital General Universitario de Alicante., Marín Ortuño F, Pineda Rocamora J, Climent Payá VE, Martínez Martínez JG, Marco Vera P, de Teresa Parreño L, Sogorb Garri F |
|---|---|
| Jazyk: | Spanish; Castilian |
| Zdroj: | Revista espanola de cardiologia [Rev Esp Cardiol] 2001 Oct; Vol. 54 (10), pp. 1155-60. |
| DOI: | 10.1016/s0300-8932(01)76473-1 |
| Abstrakt: | Introduction: Anticoagulation is rarely indicated in patients with left ventricular dysfunction who show an increased risk for thromboembolism. In theory, the three arms of the Virchow' triad may be present: abnormal blood flow, endothelial damage and prothrombotic markers. The aim of this study was to identify the last two arms. Patients and Method: We studied 82 consecutive patients with demonstrated ischaemic heart disease and sinus rhythm, and compared them with a control group comprised of 32 healthy subjects matched for age and sex. None or the patients had had an acute coronary event or hemodynamic decompensation within the 3 months prior to inclusion in the study. The plasma concentration or von Willebrand factor and fibrin d-dimer and fibrinogen were determined as endothelial damage and prothrombotic markers, respectively. A fractional shortening less than 29% by echography was defined as ventricular systolic dysfunction. Results: The patients showed significantly higher levels of von Willebrand factor with respect to the control group (109.2 31.9 vs 85.5 32.6%, p < 0.01), with no differences in fibrinogen and fibrin d-dimer values. Twenty-six patients fulfilled criteria of left ventricular systolic dysfunction. Patients with left ventricular dysfunction showed higher fibrinogen (386 118 vs 322 102 mg/dl, p = 0.03) and fibrin d-dimer (0.36 0.22 vs 0.26 0.10 g/ml; p = 0.04) levels, with no differences in von Willebrand factor levels. Conclusions: After acute coronary events, patients with ischaemic heart disease show markers of endothelial damage. However, patients with left ventricular dysfunction show a hypercoagulable state. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|