| Autor: |
Zavodnik LB; Laboratory of Experimental Hepatology, Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno, 230017 Belarus., Sushko LI, Tarasov IuA, Ignatenko KV, Chumachenko SS, Ovchinnikov VA, Brzosko V, Buko VU |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2001 Jul-Aug; Vol. 64 (4), pp. 59-62. |
| Abstrakt: |
The antioxidant and radioprotector properties of gamma-linolenic acid isolated from the seeds of Borago officialis were studied on rats gamma-irradiated to a dose of 1 Gy. The irradiation caused an increase in the content of malonaldehyde in microsomal liver fraction and disturbed the metabolism of xenobiotics. The administration of gamma-linolenic acid in the form of a commercial drug Neoglandin (daily dose, 150 mg/kg, p.o.; over 1, 3, or 7 days after irradiation reduced the level of lipid peroxidation (for all treatment schedules), normalized the activity of NADPH-oxidase, NADH-oxidase, and NADPH-reductase, and increased the content of cytochromes P-450 and b5 as compared to bothirradiated and control animals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
