| Autor: |
Mannerkoski MK; Department of Child Neurology, Hospital for Children and Adolescents, University of Helsinki, Finland., Heiskala HJ, Santavuori PR, Pouttu JA |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2001; Vol. 5 Suppl A, pp. 175-7. |
| DOI: |
10.1053/ejpn.2000.0457 |
| Abstrakt: |
We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease. The effect of a transdermal fentanyl patch was studied in five children with INCL. In two of them, measurements of 17 fentanyl serum concentrations and also visual analogue pain scale were obtained during a 15-day study period. Low doses of transdermal fentanyl usually provided good pain relief for the first two days, but not for the third day, of the three-day patch change interval. Pain relief of this type seems mandatory for pains mostly of central origin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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