| Autor: |
Fry TJ; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 13N240, 10 Center Drive, MSC 1928, Bethesda, MD 20892-1928, USA., Mackall CL |
| Jazyk: |
angličtina |
| Zdroj: |
Trends in immunology [Trends Immunol] 2001 Oct; Vol. 22 (10), pp. 564-71. |
| DOI: |
10.1016/s1471-4906(01)02028-2 |
| Abstrakt: |
Recent evidence has implicated interleukin-7 (IL-7) as a master regulator of T-cell homeostasis, based upon its essential role in the homeostatic expansion of naive T-cell populations in response to low-affinity antigens (Ags) and its capacity to enhance dramatically the expansion of peripheral T-cell populations in response to high-affinity Ags. Furthermore, T-cell-depleted humans have a unique inverse relationship between the peripheral CD4(+) T-cell count and the level of circulating IL-7. Together, these data suggest that increased amounts of IL-7 become available following T-cell depletion, thus, enhancing the high- and low-affinity Ag-driven expansion of the population of residual, mature T cells and boosting thymic regenerative capacity, as a means to restore T-cell homeostasis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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