| Autor: |
Barbeau P; Georgia Prevention Institute, Medical College of Georgia, Augusta 30912, USA. pbarbeau@mail.mcg.edu, Woods KF, Ramsey LT, Litaker MS, Pollock DM, Pollock JS, Callahan LA, Kutlar A, Mensah GA, Gutin B |
| Jazyk: |
angličtina |
| Zdroj: |
Endothelium : journal of endothelial cell research [Endothelium] 2001; Vol. 8 (2), pp. 147-55. |
| DOI: |
10.3109/10623320109165323 |
| Abstrakt: |
The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p >.05). TNFalpha was higher in SCA than controls (p < or = .0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p < or = .05). NOx increased significantly after exercise (p < or = .0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p < or = .05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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