| Autor: |
Bercu BB; Department of Pediatrics, University of South Florida, Tampa, USA. Bercub@allkids.org, Murray FT, Frasier SD, Rudlin C, O'Dea LS, Brentzel J, Hanson B, Landy H |
| Jazyk: |
angličtina |
| Zdroj: |
Endocrine [Endocrine] 2001 Jun; Vol. 15 (1), pp. 43-9. |
| DOI: |
10.1385/endo:15:1:043 |
| Abstrakt: |
In an open-label study, 69 children with organic or idiopathic growth hormone deficiency (GHD) were treated with recombinant human growth hormone (Saizen) for an average of 64.4 mo, with treatment periods as long as 140.9 mo. Auxologic measurements, including height velocity, height standard deviation score, and bone age, were made on a regular basis. The data suggest that long-term treatment with Saizen in children with GHD results in a positive catch-up growth response and proportionate changes in bone age vs height age during treatment. In addition, long-term Saizen therapy was well tolerated, with the majority of adverse events related to common childhood disorders or existing baseline medical conditions and not to study treatment. There were no significant changes in laboratory safety data or vital signs, and no positive antibody tests for Saizen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink