| Autor: |
Massoud MN; Department of Paediatrics, Faculty of Medicine, University of Alexandria, Alexandria, Egypt., el-Nawawy AA, el-Nazar SY, Abdel-Rahman GM |
| Jazyk: |
angličtina |
| Zdroj: |
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit [East Mediterr Health J] 2000 Mar-May; Vol. 6 (2-3), pp. 432-6. |
| Abstrakt: |
We assessed tumour necrosis factor-alpha (TNF-alpha) concentrations in 80 asthmatic children, 26 with severe asthma in early-phase reaction, 26 with severe asthma in late-phase reaction, 28 with severe asthma controlled in between attacks with oral prednisone and 20 matched control children. TNF-alpha was measured in patients' plasma and in a supernatant of lipopolysaccharide-stimulated (LPS) peripheral blood mononuclear (PBM) cells. TNF-alpha concentrations in plasma and the supernatant of LPS-stimulated cells were positively correlated and the concentration also correlated positively with the time lapse between the start of the asthma attack and the time of blood sampling. TNF-alpha concentration was significantly higher in the late-phase reaction group compared to the other groups, indicating a need to counteract its release and/or effects early in asthma patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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