Stupor from lamotrigine toxicity.
| Autor: | Sbei M; Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA., Campellone JV |
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| Jazyk: | angličtina |
| Zdroj: | Epilepsia [Epilepsia] 2001 Aug; Vol. 42 (8), pp. 1082-3. |
| DOI: | 10.1046/j.1528-1157.2001.0420081082.x |
| Abstrakt: | Purpose: To report that acute lamotrigine poisoning may result in severe encephalopathy. Methods: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy. Results: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels. Conclusions: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status. |
| Databáze: | MEDLINE |
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