[Modulation of behavior of mice of different genotypes by serotonin antibodies].

Autor: Mikovskaia OI; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow., Vetrilé LA, Trekova NA, Basharova LA, Evseev VA
Jazyk: ruština
Zdroj: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 2001 Mar-Apr; Vol. 51 (2), pp. 190-6.
Abstrakt: The effect of active immunization with conjugated serotonin-protein on the "open-field" behaviour and passive avoidance conditioning was studied in genetically different mice strains (C57BL/6 and BALB/c). The obtained immunophysiological effects of serotonin antibodies depended on genetically determined characteristics of animal behaviour. Serotonin antibodies altered rearing and crossings of the "open-field" center and retention of passive avoidance learning in C57BL/6 mice. The active immunization with conjugated serotonin-protein of BALB/c mice resulted in modulation of the "open-field" latency and both training and testing of passive avoidance behaviour.
Databáze: MEDLINE