| Autor: |
Mercurio AM; Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA. amercuri@caregroup.harvard.edu, Rabinovitz I, Shaw LM |
| Jazyk: |
angličtina |
| Zdroj: |
Current opinion in cell biology [Curr Opin Cell Biol] 2001 Oct; Vol. 13 (5), pp. 541-5. |
| DOI: |
10.1016/s0955-0674(00)00249-0 |
| Abstrakt: |
Although the involvement of alpha 6 beta 4, an integrin laminin receptor, in hemidesmosome organization has dominated the study of this integrin, recent studies are revealing novel functions for alpha 6 beta 4 in the migration of epithelial and carcinoma cells. The engagement of laminin by alpha 6 beta 4 can stabilize actin-rich protrusions and mediate traction forces necessary for cell movement. This integrin also has a significant impact on signaling molecules that stimulate migration and invasion, especially PI3-K and Rho GTPases. Activation of PI3-K by alpha 6 beta 4 enhances the formation of actin protrusions, and it may stimulate the function of other integrins, such as alpha 3 beta 1, that are also important for epithelial migration. Signaling through alpha 6 beta 4 may not always depend on the adhesive functions of this integrin, a possibility that has profound implications for migration and invasion because it implies that the ability of alpha 6 beta 4 to stimulate these processes is not limited to specific matrix environments. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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