[Long-term effects of captopril treatment on the course of stable effort angina pectoris and structural-functional characteristics of platelets in patients with hypertension and ischemic heart disease].
| Autor: | Shafer MZh, Gul'tiaeva EP, Gapon LI, Alfimova TV |
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| Jazyk: | ruština |
| Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 2001; Vol. 73 (7), pp. 64-7. |
| Abstrakt: | Aim: To assess clinical efficacy and effect on platelet alterations of 12-month captopril monotherapy in essential hypertension (EH) patients with coronary heart disease (CHD). Material and Methods: A randomized placebo-controlled parallel study was performed. Arterial blood pressure (BP), frequency of angina pain attacks, standard submaximal bicycle exercise test (BET), echocardiography, ADP-induced platelet aggregation (PA), levels of cholesterol (CH), lipid peroxidation products, intracellular Ca, Ca(++)-ATPase activity were studied before and 2 weeks, 2, 6 and 12 months after captopril therapy in 68 males aged 35-58 years with moderate EH in combination with CHD, stable angina of effort and normal left ventricular ejection fraction (57.5 +/- 1.2%). Results: In spite of a stable antihypertensive effect of C within all the treatment period, frequency of anginal pain attacks and number of positive BET markedly reduced only during 6 months of C therapy. Left ventricular hypertrophy regression was not registered. Of all the platelet parameters only Ca(++)-ATPase, Ca and malonic dialdehyde (MDA) beneficial changes persisted for 12 month treatment period: Ca(++)-ATPase activity increased, Ca and MDA content reduced. The other platelet parameters were less persistent. BP lowering correlated with Ca(++)-ATPase, CH, MDA and PA changes whereas the number of anginal pain attack correlated with CH and PA reduction. Conclusion: A beneficial effect of captopril on BP persisted for 12 months, on angina symptoms--for 6 months. One of the mechanisms of antihypertensive and antianginal effect of captopril is attributed to platelet alterations correction. |
| Databáze: | MEDLINE |
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