[Induction of co-stimulatory molecules on the surface of blast cells in patients with acute myeloid leukemia].
| Autor: | Sadovnikova EIu, Strel'nikova TB, Parovichnikova EN, Savchenko VG |
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| Jazyk: | ruština |
| Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 2001; Vol. 73 (7), pp. 34-40. |
| Abstrakt: | Aim: To compare the capacity of ionophore for calcium ions and growth factors (granulocytic-macrophagal colony-stimulating factor, interleukin-4, tumor necrosis factor) to induce costimulatory molecules on the surface of blast cells from patients with acute myeloid leukemia (AML). Materials and Methods: The study was carried out in 6 patients with primary and resistant AML using culturing and flow cytometry. Results: Blast cells obtained from patients during diagnosis of AML and after drug therapy of resistant AML acquire the dendrite phenotype under the effects of growth factors and Ca ion ionophore. Conclusion: Calcium metabolism modulators can be used for creation of antileukemic vaccines. |
| Databáze: | MEDLINE |
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