| Autor: |
Buckle DR, Cantello BC, Morgan NJ, Smith H, Spicer BA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1975 Jul; Vol. 18 (7), pp. 733-6. |
| DOI: |
10.1021/jm00241a018 |
| Abstrakt: |
Selected omega-nitroacetophenones, formed by the alcoholic cleavage of 2-nitroindandiones, have been shown to inhibit the homocytotropic antibody-antigen induced passive cutaneous analhylaxis reaction in the rat. The enzymatic cyclization of these derivatives to the parent nitroindandione has been demonstrated both in vivo and in vitro and this process is suggested as a possible prerequisite to biological activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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