Hepatitis C virus and GBV-C/hepatitis G virus in Argentine patients with porphyria cutanea tarda.

Autor:	Oubiña JR; Department of Microbiology, Faculty of Medicine, University of Buenos Aires, Paraguay 2155, Piso 11, 1121 Buenos Aires, Argentina. joubina@fmed.uba.ar, Quarleri JF, Sawicki MA, Mathet VL, Ruiz V, Schroder T, Méndez M, Parera V, Muramatsu H, Battle A, González Cappa SM, Fainboim HA
Jazyk:	angličtina
Zdroj:	Intervirology [Intervirology] 2001; Vol. 44 (4), pp. 215-8.
DOI:	10.1159/000050049
Abstrakt:	To investigate hepatitis C virus (HCV) and GBV-C/hepatitis G virus (HGV) genotype prevalence among HCV-infected porphyria cutanea tarda (PCT) patients, 19 HCV-infected patients with associated PCT were studied. A control group of 53 age-matched HCV-infected patients without associated PCT was selected. Eighteen of the 19 serologically positive HCV-PCT patients showed HCV RNA in serum. Genotype 1b was the most prevalent among both HCV-PCT patients (72.2%; 13/18) and age-matched HCV controls (50.9%; 27/53). Such different genotypic prevalence failed to reach statistical significance (chi(2) with Yates' correction, p = 0.19). The single HCV-PCT patient without detectable HCV RNA was also infected with genogroup 3 GBV-C/HGV. This GBV-C/HGV RNA prevalence (5.3%) among HCV-PCT patients is not statistically different from that observed among Argentine blood donors (5.5%; 11/200). To our knowledge, these results show for the first time the molecular epidemiology of both HCV and GBV-C/HGV associated to PCT in America. (Copyright 2001 S. Karger AG, Basel)
Databáze:	MEDLINE
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