| Autor: |
Chen XQ; Department of Neurobiology, Institute of Neuroscience Research, Second Military Medical University, Shanghai 200433., Chen ZY, Lu CL, He C, Wang CH, Bao X |
| Jazyk: |
čínština |
| Zdroj: |
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 1999 Oct; Vol. 51 (5), pp. 501-7. |
| Abstrakt: |
The effects of ciliary neurotrophic factor on nitric oxide (NO)-induced cytotoxicity were examined in primary cultures of rat hippocampal neurons. The neurotoxicity was induced by NO donors, such as sodium nitroprusside (SNP), s-nitroso-N-acetylpenicillamine (SNAP), NOS substrate, L-arginine (L-Arg) and ionomycin (a calcium ionophore). Preincubation of the cultures with ciliary neurotrophic factor (CNTF) for 24 h promoted neuronal survival and decreased the LDH efflux and the level of NO induced by ionomycin. The protective effects of CNTF against NO cytotoxicity were concentration-dependent. The above findings suggest that CNTF promotes the survival of neurons in the hippocampus by preventing NO mediated neurotoxicity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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