| Autor: |
Ogawa Y; Department of Radiology, Kochi Medical School, Oko-cho, Nankoku-shi, Kochi-Prefecture 783-8505, Japan. ogaway/kms@kochi-ms.ac.jp, Kobayashi T, Nishioka A, Kariya S, Garcia Del Saz E, Seguchi H, Yoshida S |
| Jazyk: |
angličtina |
| Zdroj: |
Oncology reports [Oncol Rep] 2001 Sep-Oct; Vol. 8 (5), pp. 1027-9. |
| DOI: |
10.3892/or.8.5.1027 |
| Abstrakt: |
The effectiveness of granulocyte colony-stimulating factor (G-CSF) for granulocytopenia has been widely recognized. However, although granulocyte counts rapidly increase after a few injection of G-CSF, a large proportion of the increased granulocytes disappear from peripheral blood within a few days following G-CSF withdrawal. Where do they go? In this report, the answer can be seen at a glance. Using MitoCapture and a CCD camera-equipped fluorescence microscope, we succeeded in demonstrating that G-CSF withdrawal induced loss of mitochondrial membrane potential, i.e., an early stage of apoptosis, in human peripheral granulocytes increased by G-CSF. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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