Basal metabolic rate in children with a solid tumour.
| Autor: | den Broeder E; Department of Paediatrics, University Hospital Nijmegen, The Netherlands. edenbroeder@hotmail.com, Oeseburg B, Lippens RJ, van Staveren WA, Sengers RC, van't Hof MA, Tolboom JJ |
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| Jazyk: | angličtina |
| Zdroj: | European journal of clinical nutrition [Eur J Clin Nutr] 2001 Aug; Vol. 55 (8), pp. 673-81. |
| DOI: | 10.1038/sj.ejcn.1601199 |
| Abstrakt: | Objective: To study the level of and changes in basal metabolic rate (BMR) in children with a solid tumour at diagnosis and during treatment in order to provide a more accurate estimate of energy requirements for nutritional support. Design: An observational study. Setting: Tertiary care at the Centre for Paediatric Oncology, University Hospital Nijmegen. Subjects: Thirteen patients were recruited from a population of patients visiting the University Hospital Nijmegen for treatment. All patients asked to participate took part in and completed the study. Intervention: BMR was measured by indirect calorimetry, under stringent, standardised conditions, for 20 min and on three different occasions in all patients. Continuous breath gas analysis using a mouthpiece was performed. Weight, height and skinfold measurements were performed before each measurement. Main Outcome Measures: BMR was expressed as percentage of the estimated reference value, according to the Schofield formulas based on age, weight and sex, and in kJ (kcal) per kg of fat-free mass. Results: At diagnosis, the BMR was higher than the estimated reference BMR in all patients and 44% of the patients were considered hypermetabolic. Mean BMR (as percentage of reference) was significantly increased (11.6% (s.d. 6.7%); P=0.001), but decreased during treatment in 12 of the 13 patients (mean decrease 12.7% (s.d. 3.9%); P<0.0001). Furthermore, a significant negative correlation (P=-0.67; P=0.01) was found between the change in BMR and tumour response. Conclusions: These data suggest that the BMR of children with a solid tumour is increased at diagnosis and possibly during the first phase of oncologic treatment. This may be important when determining energy requirements for nutritional support. |
| Databáze: | MEDLINE |
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