| Autor: |
Patel M; DuPont Pharmaceuticals Company, Experimental Station, E500/4803, PO Box 80500, 19880-0500, Wilmington, DE, USA. mpatel5@prius.jnj.com, McHugh RJ Jr, Cordova BC, Klabe RM, Bacheler LT, Erickson-Viitanen S, Rodgers JD |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Jul 23; Vol. 11 (14), pp. 1943-5. |
| DOI: |
10.1016/s0960-894x(01)00331-6 |
| Abstrakt: |
A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect